Phenotypic lentivirus screens to identify functional single domain antibodies

Manipulation of proteins is key in assessing their in vivo function. While genetic ablation is straightforward, reversible and specific perturbation of protein function remains a challenge. Single domain antibody fragments, such as camelid-derived VHHs, can serve as inhibitors or activators of intra...

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Detalles Bibliográficos
Autores principales: Schmidt, Florian I., Hanke, Leo, Morin, Benjamin, Brewer, Rebeccah, Brusic, Vesna, Whelan, Sean P.J., Ploegh, Hidde L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010022/
https://www.ncbi.nlm.nih.gov/pubmed/27573105
http://dx.doi.org/10.1038/nmicrobiol.2016.80

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010022/
https://www.ncbi.nlm.nih.gov/pubmed/27573105
http://dx.doi.org/10.1038/nmicrobiol.2016.80

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