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Phenotypic lentivirus screens to identify functional single domain antibodies
Manipulation of proteins is key in assessing their in vivo function. While genetic ablation is straightforward, reversible and specific perturbation of protein function remains a challenge. Single domain antibody fragments, such as camelid-derived VHHs, can serve as inhibitors or activators of intra...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010022/ https://www.ncbi.nlm.nih.gov/pubmed/27573105 http://dx.doi.org/10.1038/nmicrobiol.2016.80 |