Rescue of mitochondrial function in parkin-mutant fibroblasts using drug loaded PMPC-PDPA polymersomes and tubular polymersomes

Mutations in parkin cause autosomal recessive Parkinsonism and mitochondrial defects. A recent drug screen identified a class of steroid-like hydrophobic compounds able to rescue mitochondrial function in parkin-mutant fibroblasts. Whilst these possess therapeutic potential, the size and high hydrop...

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Detalles Bibliográficos
Autores principales: Yealland, G., Battaglia, G., Bandmann, O., Mortiboys, H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Scientific Publishers Ireland 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010038/
https://www.ncbi.nlm.nih.gov/pubmed/27412236
http://dx.doi.org/10.1016/j.neulet.2016.06.065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010038/
https://www.ncbi.nlm.nih.gov/pubmed/27412236
http://dx.doi.org/10.1016/j.neulet.2016.06.065

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