Discovery of Potential Orthosteric and Allosteric Antagonists of P2Y1R from Chinese Herbs by Molecular Simulation Methods

P2Y1 receptor (P2Y1R), which belongs to G protein-coupled receptors (GPCRs), is an important target in ADP-induced platelet aggregation. The crystal structure of P2Y1R has been solved recently, which revealed orthosteric and allosteric ligand-binding sites with the details of ligand-protein binding...

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Detalles Bibliográficos
Autores principales: Zhang, Xu, Lu, Fang, Chen, Yan-kun, Luo, Gang-gang, Jiang, Lu-di, Qiao, Lian-sheng, Zhang, Yan-ling, Xiang, Yu-hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011212/
https://www.ncbi.nlm.nih.gov/pubmed/27635149
http://dx.doi.org/10.1155/2016/4320201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011212/
https://www.ncbi.nlm.nih.gov/pubmed/27635149
http://dx.doi.org/10.1155/2016/4320201

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