Cargando…

A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine

A 90-day repeated-dose oral toxicological evaluation was conducted according to GLP and OECD guidelines on the methylurate purine alkaloid theacrine, which is found naturally in certain plants. Four groups of Hsd.Brl.Han Wistar rats (ten/sex/group) were administered theacrine by gavage doses of 0 (v...

Descripción completa

Detalles Bibliográficos
Autores principales:	Clewell, Amy, Hirka, Gábor, Glávits, Róbert, Palmer, Philip A., Endres, John R., Murbach, Timothy S., Marx, Tennille, Pasics Szakonyiné, Ilona
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011229/ https://www.ncbi.nlm.nih.gov/pubmed/27635133 http://dx.doi.org/10.1155/2016/6206859

Ejemplares similares

A 28-day oral toxicology study of an aqueous extract of Polypodium leucotomos (Fernblock(®))
por: Murbach, Timothy S., et al.
Publicado: (2017)

A Toxicological Evaluation of Methylliberine (Dynamine®)
por: Murbach, Timothy S., et al.
Publicado: (2019)

A toxicological evaluation of a fulvic and humic acids preparation
por: Murbach, Timothy S., et al.
Publicado: (2020)

Toxicological Evaluation of a Mixture of Astragalus membranaceus and Panax notoginseng Root Extracts (InnoSlim®)
por: Murbach, Timothy S., et al.
Publicado: (2019)

A Toxicological Evaluation of Germanium Sesquioxide (Organic Germanium)
por: Reddeman, Robin A., et al.
Publicado: (2020)

A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin
por: Reddeman, Robin A., et al.
Publicado: (2019)

An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp
por: Marx, Tennille K., et al.
Publicado: (2018)

1-Methyluric Acid Nephropathy
por: Zaworski, Jeremy, et al.
Publicado: (2020)

Effects of Theacrine as a Pre-Workout Supplement
por: Cerqueira, Henrique Santa Capita, et al.
Publicado: (2022)

Theacrine From Camellia kucha and Its Health Beneficial Effects
por: Sheng, Yue-Yue, et al.
Publicado: (2020)

Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea
por: Zhang, Yue-Hong, et al.
Publicado: (2020)

Novel insight into theacrine metabolism revealed by transcriptome analysis in bitter tea (Kucha, Camellia sinensis)
por: Wang, Songlin, et al.
Publicado: (2020)

Attenuation of Tumor Development in Mammary Carcinoma Rats by Theacrine, an Antagonist of Adenosine 2A Receptor
por: Jhuo, Cian-Fen, et al.
Publicado: (2021)

Identification of Co-Expressed Genes Related to Theacrine Synthesis in Tea Flowers at Different Developmental Stages
por: Chen, Xiaomin, et al.
Publicado: (2021)

Biological Activities of Alkaloids: From Toxicology to Pharmacology
por: Adamski, Zbigniew, et al.
Publicado: (2020)

Theacrine alleviates sepsis-induced acute kidney injury by repressing the activation of NLRP3/Caspase-1 inflammasome
por: Yang, Maoxian, et al.
Publicado: (2022)

Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety
por: Moreira, Rute, et al.
Publicado: (2018)

Comparative Analysis of Purine Alkaloids and Main Quality Components of the Three Camellia Species in China
por: Zeng, Wen, et al.
Publicado: (2022)

Hepatotoxicity of Pyrrolizidine Alkaloid Compound Intermedine: Comparison with Other Pyrrolizidine Alkaloids and Its Toxicological Mechanism
por: Wang, Ziqi, et al.
Publicado: (2021)

Pyrrolizidine alkaloid-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides
por: He, Xiaobo, et al.
Publicado: (2017)

A Purine Analog Synergizes with Chloroquine (CQ) by Targeting Plasmodium falciparum Hsp90 (PfHsp90)
por: Shahinas, Dea, et al.
Publicado: (2013)

Cognitive Performance and Mood Following Ingestion of a Theacrine-Containing Dietary Supplement, Caffeine, or Placebo by Young Men and Women
por: Kuhman, Daniel J., et al.
Publicado: (2015)

A Mitochondrial-targeted purine-based HSP90 antagonist for leukemia therapy
por: Bryant, Kelly G., et al.
Publicado: (2017)

Novel Purine Alkaloid Cocrystals with Trimesic and Hemimellitic Acids as Coformers: Synthetic Approach and Supramolecular Analysis
por: Gołdyn, M. R., et al.
Publicado: (2020)

A novel TcS allele conferring the high-theacrine and low-caffeine traits and having potential use in tea plant breeding
por: Zhong, Hong, et al.
Publicado: (2022)

Purine metabolism in sprint- vs endurance-trained athletes aged 20‒90 years
por: Zieliński, Jacek, et al.
Publicado: (2019)

Baiyacha, a wild tea plant naturally occurring high contents of theacrine and 3″-methyl-epigallocatechin gallate from Fujian, China
por: Jin, Ji-Qiang, et al.
Publicado: (2020)

Effects of caffeine, methylliberine, and theacrine on vigilance, marksmanship, and hemodynamic responses in tactical personnel: a double-blind, randomized, placebo-controlled trial
por: Cintineo, Harry P., et al.
Publicado: (2022)

Safety of Teacrine(®), a Non-Habituating, Naturally-Occurring Purine Alkaloid Over Eight Weeks of Continuous Use
por: Hayward, Sara, et al.
Publicado: (2015)

The Purins
por: Hopkins, Henry Reed
Publicado: (1910)

Structural Basis for Design of New Purine-Based Inhibitors Targeting the Hydrophobic Binding Pocket of Hsp90
por: Shin, Sang Chul, et al.
Publicado: (2020)

Purine biosynthetic enzymes assemble into liquid-like condensates dependent on the activity of chaperone protein HSP90
por: Pedley, Anthony M., et al.
Publicado: (2022)

Safety of TeaCrine®, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use
por: Taylor, Lem, et al.
Publicado: (2016)

The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1
por: Usmani, Saad Z, et al.
Publicado: (2010)

A Combination of Caffeine, TeaCrine® (Theacrine), and Dynamine® (Methylliberine) Increases Cognitive Performance and Reaction Time Without Interfering With Mood in Adult Male Egamers
por: Tartar, Jaime L, et al.
Publicado: (2021)

THE PURINES AND PURINE METABOLISM OF SOME TUMORS IN DOMESTIC ANIMALS
por: Long, Esmond R.
Publicado: (1913)

Investigation of free amino acid, total phenolics, antioxidant activity and purine alkaloids to assess the health properties of non-Camellia tea
por: Bi, Wu, et al.
Publicado: (2016)

A Theacrine-Based Supplement Increases Cellular NAD(+) Levels and Affects Biomarkers Related to Sirtuin Activity in C2C12 Muscle Cells In Vitro
por: Mumford, Petey W., et al.
Publicado: (2020)

A pragmatic framework for the application of new approach methodologies in one health toxicological risk assessment
por: Magurany, Kelly A, et al.
Publicado: (2023)

Interactions of 2,6-substituted purines with purine nucleoside phosphorylase from Helicobacter pylori in solution and in the crystal, and the effects of these compounds on cell cultures of this bacterium
por: Narczyk, Marta, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_m50h12lfhbosua4t2hp9fk168k