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Ganglioside GM3 synthase depletion reverses neuropathic pain and small fiber neuropathy in diet-induced diabetic mice

BACKGROUND: Small fiber neuropathy is a well-recognized complication of type 2 diabetes and has been shown to be responsible for both neuropathic pain and impaired wound healing. In previous studies, we have demonstrated that ganglioside GM3 depletion by knockdown of GM3 synthase fully reverses impa...

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Detalles Bibliográficos
Autores principales: Menichella, Daniela M, Jayaraj, Nirupa D, Wilson, Heather M, Ren, Dongjun, Flood, Kelsey, Wang, Xiao-Qi, Shum, Andrew, Miller, Richard J, Paller, Amy S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011393/
https://www.ncbi.nlm.nih.gov/pubmed/27590073
http://dx.doi.org/10.1177/1744806916666284