Triptonide Effectively Inhibits Wnt/β-Catenin Signaling via C-terminal Transactivation Domain of β-catenin

Abnormal activation of canonical Wnt/β-catenin signaling is implicated in many diseases including cancer. As a result, therapeutic agents that disrupt this signaling pathway have been highly sought after. Triptonide is a key bioactive small molecule identified in a traditional Chinese medicine named...

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Detalles Bibliográficos
Autores principales: Chinison, Jessica, Aguilar, Jose S., Avalos, Alan, Huang, Ying, Wang, Zhijun, Cameron, D. Joshua, Hao, Jijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011721/
https://www.ncbi.nlm.nih.gov/pubmed/27596363
http://dx.doi.org/10.1038/srep32779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011721/
https://www.ncbi.nlm.nih.gov/pubmed/27596363
http://dx.doi.org/10.1038/srep32779

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