Tylophorine Analog DCB-3503 Inhibited Cyclin D1 Translation through Allosteric Regulation of Heat Shock Cognate Protein 70

Tylophorine analog DCB-3503 is a potential anticancer and immunosuppressive agent that suppresses the translation of cellular regulatory proteins, including cyclin D1, at the elongation step. However, the molecular mechanism underlying this phenomenon remains unknown. This study demonstrates that DC...

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Detalles Bibliográficos
Autores principales: Wang, Ying, Lam, Wing, Chen, Shao-Ru, Guan, Fu-Lan, Dutchman, Ginger E., Francis, Samson, Baker, David C., Cheng, Yung-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011780/
https://www.ncbi.nlm.nih.gov/pubmed/27596272
http://dx.doi.org/10.1038/srep32832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011780/
https://www.ncbi.nlm.nih.gov/pubmed/27596272
http://dx.doi.org/10.1038/srep32832

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