Cargando…

Tylophorine Analog DCB-3503 Inhibited Cyclin D1 Translation through Allosteric Regulation of Heat Shock Cognate Protein 70

Tylophorine analog DCB-3503 is a potential anticancer and immunosuppressive agent that suppresses the translation of cellular regulatory proteins, including cyclin D1, at the elongation step. However, the molecular mechanism underlying this phenomenon remains unknown. This study demonstrates that DC...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Ying, Lam, Wing, Chen, Shao-Ru, Guan, Fu-Lan, Dutchman, Ginger E., Francis, Samson, Baker, David C., Cheng, Yung-Chi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011780/ https://www.ncbi.nlm.nih.gov/pubmed/27596272 http://dx.doi.org/10.1038/srep32832

Ejemplares similares

DCB-3503, a Tylophorine Analog, Inhibits Protein Synthesis through a Novel Mechanism
por: Wang, Ying, et al.
Publicado: (2010)

Tylophorine Analogs Allosterically Regulates Heat Shock Cognate Protein 70 And Inhibits Hepatitis C Virus Replication
por: Wang, Ying, et al.
Publicado: (2017)

Cryptopleurine Analogs with Modification of E Ring Exhibit Different Mechanism to Rac-Cryptopleurine and Tylophorine
por: Wang, Ying, et al.
Publicado: (2012)

Tylophorine: Sources, Properties, Applications and Biotechnological Production
por: Cyriac, Angeline, et al.
Publicado: (2020)

3503 Restrictive feeding and excessive hunger in young children with obesity: A case series
por: Eagleton, Sally Grace, et al.
Publicado: (2019)

The 70-kD heat shock cognate protein (hsc70) facilitates the nuclear export of the import receptors
por: Kose, Shingo, et al.
Publicado: (2005)

Gallus Heat shock cognate protein 70, a novel binding partner of Apoptin
por: Chen, Kun, et al.
Publicado: (2011)

Diosgenin restores Aβ-induced axonal degeneration by reducing the expression of heat shock cognate 70 (HSC70)
por: Yang, Ximeng, et al.
Publicado: (2018)

Connexin43 Functions as a Novel Interacting Partner of Heat Shock Cognate Protein 70
por: Hatakeyama, Tomoya, et al.
Publicado: (2013)

Ex vivo promoter analysis of antiviral heat shock cognate 70B gene in Anopheles gambiae
por: Kang, Seokyoung, et al.
Publicado: (2008)

EEVD motif of heat shock cognate protein 70 contributes to bacterial uptake by trophoblast giant cells
por: Watanabe, Kenta, et al.
Publicado: (2009)

Anti-HBV efficacy of combined siRNAs targeting viral gene and heat shock cognate 70
por: Bian, Zhongqi, et al.
Publicado: (2012)

Heat Shock Cognate Protein 70 Enhanced Integrin β1 Mediated Invasion in Cancer Cells
por: Sun, Guan, et al.
Publicado: (2020)

Adaptive Mechanisms of Shewanella xiamenensis DCB 2-1 Metallophilicity
por: Abuladze, Marina, et al.
Publicado: (2023)

Exploration of the cysteine reactivity of human inducible Hsp70 and cognate Hsc70
por: Hong, Zhouping, et al.
Publicado: (2022)

Heat shock cognate protein 70 contributes to Brucella invasion into trophoblast giant cells that cause infectious abortion
por: Watanabe, Kenta, et al.
Publicado: (2008)

Anopheles gambiae heat shock protein cognate 70B impedes o'nyong-nyong virus replication
por: Sim, Cheolho, et al.
Publicado: (2007)

Engineering heat tolerance in potato by temperature‐dependent expression of a specific allele of HEAT‐SHOCK COGNATE 70
por: Trapero‐Mozos, Almudena, et al.
Publicado: (2017)

The stress protein heat shock cognate 70 (Hsc70) inhibits the Transient Receptor Potential Vanilloid type 1 (TRPV1) channel
por: Iftinca, Mircea, et al.
Publicado: (2016)

A Study on the Susceptibility to SCC of 7050 Aluminum Alloy by DCB Specimens
por: Qi, Xing, et al.
Publicado: (2016)

Experimental and numerical study on DCB specimens bonded with similar and dissimilar materials
por: Ma, Mingze, et al.
Publicado: (2022)

Antibodies against 70-kD heat shock cognate protein inhibit mediated nuclear import of karyophilic proteins
Publicado: (1992)

Heat Shock Cognate 70 Functions as A Chaperone for the Stability of Kinetochore Protein CENP-N in Holocentric Insect Silkworms
por: Li, Bingqian, et al.
Publicado: (2019)

The Role of the Heat Shock Cognate Protein 70 Genes in Sex Determination and Differentiation of Chinese Tongue Sole (Cynoglossus semilaevis)
por: Liu, Qian, et al.
Publicado: (2023)

Impact of Scoring Balloon Angioplasty on Lesion Preparation for DCB Treatment of Coronary Lesions
por: Shin, Eun-Seok, et al.
Publicado: (2023)

70-kDa heat shock cognate protein expression as a putative biomarker of heavy-metal burden in Mytilus galloprovincialis
por: Ratkaj, Ivana, et al.
Publicado: (2015)

Heat Shock 70 kDa Protein Cognate 3 of Brown Planthopper Is Required for Survival and Suppresses Immune Response in Plants
por: Yang, Houhong, et al.
Publicado: (2022)

Allosteric Activation of Bacterial Response Regulators: the Role of the Cognate Histidine Kinase Beyond Phosphorylation
por: Trajtenberg, Felipe, et al.
Publicado: (2014)

Design, Synthesis and In-Vitro Biological Evaluation of Antofine and Tylophorine Prodrugs as Hypoxia-Targeted Anticancer Agents
por: Omran, Ziad, et al.
Publicado: (2021)

Benzoindolizidine Alkaloids Tylophorine and Lycorine and Their Analogues with Antiviral, Anti-Inflammatory, and Anticancer Properties: Promises and Challenges
por: Di Sotto, Antonella, et al.
Publicado: (2023)

Heat Shock Cognate 70 Inhibitor, VER-155008, Reduces Memory Deficits and Axonal Degeneration in a Mouse Model of Alzheimer’s Disease
por: Yang, Ximeng, et al.
Publicado: (2018)

Heat Shock Cognate 70 kDa Protein Is the Target of Tetradecyl 2,3-Dihydroxybenzoate for Neuritogenic Effect in PC12 Cells
por: Cheng, Lihong, et al.
Publicado: (2021)

Small extracellular vesicles in combination with sleep-related circRNA3503: A targeted therapeutic agent with injectable thermosensitive hydrogel to prevent osteoarthritis
por: Tao, Shi-Cong, et al.
Publicado: (2021)

Heat Shock Protein 70 Inhibitors. 1. 2,5′-Thiodipyrimidine and 5-(Phenylthio)pyrimidine Acrylamides as Irreversible Binders to an Allosteric Site on Heat Shock Protein 70
por: Kang, Yanlong, et al.
Publicado: (2014)

Discovery and Nanosized Preparations of (S,R)-Tylophorine Malate as Novel anti-SARS-CoV-2 Agents
por: Wang, Ziwen, et al.
Publicado: (2021)

Heat shock cognate protein 70 encodes antigenic epitopes recognised by HLA-B4601-restricted cytotoxic T lymphocytes from cancer patients
por: Azuma, K, et al.
Publicado: (2003)

Haploinsufficiency of the E3 Ubiquitin Ligase C-Terminus of Heat Shock Cognate 70 Interacting Protein (CHIP) Produces Specific Behavioral Impairments
por: McLaughlin, BethAnn, et al.
Publicado: (2012)

A plastid-targeted heat shock cognate 70-kDa protein confers osmotic stress tolerance by enhancing ROS scavenging capability
por: Ding, Feng, et al.
Publicado: (2022)

A Small Range Six-Axis Accelerometer Designed with High Sensitivity DCB Elastic Element
por: Sun, Zhibo, et al.
Publicado: (2016)

Back to the future: DCB use instead of DES for the treatment of complex, native coronary artery disease
por: Cortese, Bernardo, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_vsvorsm3nqq9p4tklgspnklctr