Discriminating agonist and antagonist ligands of the nuclear receptors using 3D-pharmacophores

Nuclear receptors (NRs) constitute an important class of therapeutic targets. We evaluated the performance of 3D structure-based and ligand-based pharmacophore models in predicting the pharmacological profile of NRs ligands using the NRLiSt BDB database. We could generate selective pharmacophores fo...

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Detalles Bibliográficos
Autores principales: Lagarde, Nathalie, Delahaye, Solenne, Zagury, Jean-François, Montes, Matthieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011875/
https://www.ncbi.nlm.nih.gov/pubmed/27602059
http://dx.doi.org/10.1186/s13321-016-0154-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011875/
https://www.ncbi.nlm.nih.gov/pubmed/27602059
http://dx.doi.org/10.1186/s13321-016-0154-2

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