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Discriminating agonist and antagonist ligands of the nuclear receptors using 3D-pharmacophores

Nuclear receptors (NRs) constitute an important class of therapeutic targets. We evaluated the performance of 3D structure-based and ligand-based pharmacophore models in predicting the pharmacological profile of NRs ligands using the NRLiSt BDB database. We could generate selective pharmacophores fo...

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Detalles Bibliográficos
Autores principales:	Lagarde, Nathalie, Delahaye, Solenne, Zagury, Jean-François, Montes, Matthieu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011875/ https://www.ncbi.nlm.nih.gov/pubmed/27602059 http://dx.doi.org/10.1186/s13321-016-0154-2

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