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The HIV-1 late domain-2 S(40)A polymorphism in antiretroviral (or ART)-exposed individuals influences protease inhibitor susceptibility
BACKGROUND: The p6 region of the HIV-1 structural precursor polyprotein, Gag, contains two motifs, P(7)TAP(11) and L(35)YPLXSL(41), designated as late (L) domain-1 and -2, respectively. These motifs bind the ESCRT-I factor Tsg101 and the ESCRT adaptor Alix, respectively, and are critical for efficie...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011916/ https://www.ncbi.nlm.nih.gov/pubmed/27600154 http://dx.doi.org/10.1186/s12977-016-0298-1 |