The HIV-1 late domain-2 S(40)A polymorphism in antiretroviral (or ART)-exposed individuals influences protease inhibitor susceptibility

BACKGROUND: The p6 region of the HIV-1 structural precursor polyprotein, Gag, contains two motifs, P(7)TAP(11) and L(35)YPLXSL(41), designated as late (L) domain-1 and -2, respectively. These motifs bind the ESCRT-I factor Tsg101 and the ESCRT adaptor Alix, respectively, and are critical for efficie...

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Detalles Bibliográficos
Autores principales: Watanabe, Susan M., Simon, Viviana, Durham, Natasha D., Kemp, Brittney R., Machihara, Satoshi, Kemal, Kimdar Sherefa, Shi, Binshan, Foley, Brian, Li, Hongru, Chen, Benjamin K., Weiser, Barbara, Burger, Harold, Anastos, Kathryn, Chen, Chaoping, Carter, Carol A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011916/
https://www.ncbi.nlm.nih.gov/pubmed/27600154
http://dx.doi.org/10.1186/s12977-016-0298-1

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