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Pathogenesis of FUS-associated ALS and FTD: insights from rodent models

Disruptions to genes linked to RNA processing and homeostasis are implicated in the pathogenesis of two pathologically related but clinically heterogeneous neurodegenerative diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations in the Fused-in-Sarcoma (FUS) gene...

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Detalles Bibliográficos
Autores principales: Nolan, Matthew, Talbot, Kevin, Ansorge, Olaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011941/
https://www.ncbi.nlm.nih.gov/pubmed/27600654
http://dx.doi.org/10.1186/s40478-016-0358-8