Reactivation of mutant p53 by capsaicin, the major constituent of peppers

BACKGROUND: Mutations in the p53 oncosuppressor gene are highly frequent in human cancers. These alterations are mainly point mutations in the DNA binding domain of p53 and disable p53 from transactivating target genes devoted to anticancer activity. Mutant p53 proteins are usually more stable than...

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Detalles Bibliográficos
Autores principales: Garufi, Alessia, Pistritto, Giuseppa, Cirone, Mara, D’Orazi, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012067/
https://www.ncbi.nlm.nih.gov/pubmed/27599722
http://dx.doi.org/10.1186/s13046-016-0417-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012067/
https://www.ncbi.nlm.nih.gov/pubmed/27599722
http://dx.doi.org/10.1186/s13046-016-0417-9

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