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Reactivation of mutant p53 by capsaicin, the major constituent of peppers
BACKGROUND: Mutations in the p53 oncosuppressor gene are highly frequent in human cancers. These alterations are mainly point mutations in the DNA binding domain of p53 and disable p53 from transactivating target genes devoted to anticancer activity. Mutant p53 proteins are usually more stable than...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012067/ https://www.ncbi.nlm.nih.gov/pubmed/27599722 http://dx.doi.org/10.1186/s13046-016-0417-9 |