Direct Thrombin Inhibitors Prevent Left Atrial Remodeling Associated With Heart Failure in Rats

The present study tested the hypothesis that thrombin participates in formation of left atrial remodeling and that direct oral anticoagulants, such as direct thrombin inhibitors (DTIs), can prevent its progression. In a rat model of heart failure associated with left atrial dilation, we found that c...

Descripción completa

Detalles Bibliográficos
Autores principales: Jumeau, Céline, Rupin, Alain, Chieng-Yane, Pauline, Mougenot, Nathalie, Zahr, Noël, David-Dufilho, Monique, Hatem, Stéphane N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
PRE-CLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012373/
https://www.ncbi.nlm.nih.gov/pubmed/27642643
http://dx.doi.org/10.1016/j.jacbts.2016.05.002
_version_ 1782451994626097152
author Jumeau, Céline
Rupin, Alain
Chieng-Yane, Pauline
Mougenot, Nathalie
Zahr, Noël
David-Dufilho, Monique
Hatem, Stéphane N.
author_facet Jumeau, Céline
Rupin, Alain
Chieng-Yane, Pauline
Mougenot, Nathalie
Zahr, Noël
David-Dufilho, Monique
Hatem, Stéphane N.
author_sort Jumeau, Céline
collection PubMed
description The present study tested the hypothesis that thrombin participates in formation of left atrial remodeling and that direct oral anticoagulants, such as direct thrombin inhibitors (DTIs), can prevent its progression. In a rat model of heart failure associated with left atrial dilation, we found that chronic treatment with DTIs reduces the atrial remodeling and the duration of atrial fibrillation (AF) episodes induced by burst pacing by inhibiting myocardial hypertrophy and fibrosis. In addition to the prevention of thromboembolism complicating AF, DTIs may be of interest to slow down the progression of the arrhythmogenic substrate.
format Online
Article
Text
id pubmed-5012373
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-50123732016-09-14 Direct Thrombin Inhibitors Prevent Left Atrial Remodeling Associated With Heart Failure in Rats Jumeau, Céline Rupin, Alain Chieng-Yane, Pauline Mougenot, Nathalie Zahr, Noël David-Dufilho, Monique Hatem, Stéphane N. JACC Basic Transl Sci PRE-CLINICAL RESEARCH The present study tested the hypothesis that thrombin participates in formation of left atrial remodeling and that direct oral anticoagulants, such as direct thrombin inhibitors (DTIs), can prevent its progression. In a rat model of heart failure associated with left atrial dilation, we found that chronic treatment with DTIs reduces the atrial remodeling and the duration of atrial fibrillation (AF) episodes induced by burst pacing by inhibiting myocardial hypertrophy and fibrosis. In addition to the prevention of thromboembolism complicating AF, DTIs may be of interest to slow down the progression of the arrhythmogenic substrate. Elsevier 2016-07-13 /pmc/articles/PMC5012373/ /pubmed/27642643 http://dx.doi.org/10.1016/j.jacbts.2016.05.002 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle PRE-CLINICAL RESEARCH
Jumeau, Céline
Rupin, Alain
Chieng-Yane, Pauline
Mougenot, Nathalie
Zahr, Noël
David-Dufilho, Monique
Hatem, Stéphane N.
Direct Thrombin Inhibitors Prevent Left Atrial Remodeling Associated With Heart Failure in Rats
title Direct Thrombin Inhibitors Prevent Left Atrial Remodeling Associated With Heart Failure in Rats
title_full Direct Thrombin Inhibitors Prevent Left Atrial Remodeling Associated With Heart Failure in Rats
title_fullStr Direct Thrombin Inhibitors Prevent Left Atrial Remodeling Associated With Heart Failure in Rats
title_full_unstemmed Direct Thrombin Inhibitors Prevent Left Atrial Remodeling Associated With Heart Failure in Rats
title_short Direct Thrombin Inhibitors Prevent Left Atrial Remodeling Associated With Heart Failure in Rats
title_sort direct thrombin inhibitors prevent left atrial remodeling associated with heart failure in rats
topic PRE-CLINICAL RESEARCH
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012373/
https://www.ncbi.nlm.nih.gov/pubmed/27642643
http://dx.doi.org/10.1016/j.jacbts.2016.05.002
work_keys_str_mv AT jumeauceline directthrombininhibitorspreventleftatrialremodelingassociatedwithheartfailureinrats
AT rupinalain directthrombininhibitorspreventleftatrialremodelingassociatedwithheartfailureinrats
AT chiengyanepauline directthrombininhibitorspreventleftatrialremodelingassociatedwithheartfailureinrats
AT mougenotnathalie directthrombininhibitorspreventleftatrialremodelingassociatedwithheartfailureinrats
AT zahrnoel directthrombininhibitorspreventleftatrialremodelingassociatedwithheartfailureinrats
AT daviddufilhomonique directthrombininhibitorspreventleftatrialremodelingassociatedwithheartfailureinrats
AT hatemstephanen directthrombininhibitorspreventleftatrialremodelingassociatedwithheartfailureinrats

Ejemplares similares