Gene Silencing Using 4′-thioDNA as an Artificial Template to Synthesize Short Hairpin RNA Without Inducing a Detectable Innate Immune Response

The development of a versatile technique to induce RNA interference (RNAi) without immune stimulation in vivo is of interest as existing approaches to trigger RNAi, such as small interfering RNA (siRNA) and plasmid DNA (pDNA) expressing short hairpin RNA (shRNA), present drawbacks arising from innat...

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Detalles Bibliográficos
Autores principales: Tarashima, Noriko, Ando, Hidenori, Kojima, Takamitsu, Kinjo, Nozomi, Hashimoto, Yosuke, Furukawa, Kazuhiro, Ishida, Tatsuhiro, Minakawa, Noriaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012546/
https://www.ncbi.nlm.nih.gov/pubmed/26730811
http://dx.doi.org/10.1038/mtna.2015.48

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012546/
https://www.ncbi.nlm.nih.gov/pubmed/26730811
http://dx.doi.org/10.1038/mtna.2015.48

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