Design of Effective Primary MicroRNA Mimics With Different Basal Stem Conformations

Primary microRNA (pri-miRNA) mimics are important mediators of effective gene silencing and are well suited for sustained therapeutic applications. Pri-miRNA mimics are processed in the endogenous miRNA biogenesis pathway, where elements of the secondary RNA structure are crucial for efficient miRNA...

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Detalles Bibliográficos
Autores principales: van den Berg, Fiona T, Rossi, John J, Arbuthnot, Patrick, Weinberg, Marc S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012551/
https://www.ncbi.nlm.nih.gov/pubmed/26756196
http://dx.doi.org/10.1038/mtna.2015.53

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012551/
https://www.ncbi.nlm.nih.gov/pubmed/26756196
http://dx.doi.org/10.1038/mtna.2015.53

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