Biodistribution and Pharmacokinetics Study of siRNA-loaded Anti-NTSR1-mAb-functionalized Novel Hybrid Nanoparticles in a Metastatic Orthotopic Murine Lung Cancer Model

Small interfering RNA (siRNA) is effective in silencing critical molecular pathways in cancer. The use of this tool as a treatment modality is limited by lack of an intelligent carrier system to enhance the preferential delivery of this molecule to specific targets in vivo. In the present study, the...

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Detalles Bibliográficos
Autores principales: Perepelyuk, Maryna, Thangavel, Chellappagounder, Liu, Yi, Den, Robert B, Lu, Bo, Snook, Adam E, Shoyele, Sunday A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012553/
https://www.ncbi.nlm.nih.gov/pubmed/26812654
http://dx.doi.org/10.1038/mtna.2015.56

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012553/
https://www.ncbi.nlm.nih.gov/pubmed/26812654
http://dx.doi.org/10.1038/mtna.2015.56

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