Efficient Restoration of the Dystrophin Gene Reading Frame and Protein Structure in DMD Myoblasts Using the CinDel Method

The CRISPR/Cas9 system is a great revolution in biology. This technology allows the modification of genes in vitro and in vivo in a wide variety of living organisms. In most Duchenne muscular dystrophy (DMD) patients, expression of dystrophin (DYS) protein is disrupted because exon deletions result...

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Detalles Bibliográficos
Autores principales: Iyombe-Engembe, Jean-Paul, Ouellet, Dominique L, Barbeau, Xavier, Rousseau, Joël, Chapdelaine, Pierre, Lagüe, Patrick, Tremblay, Jacques P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012554/
https://www.ncbi.nlm.nih.gov/pubmed/26812655
http://dx.doi.org/10.1038/mtna.2015.58

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012554/
https://www.ncbi.nlm.nih.gov/pubmed/26812655
http://dx.doi.org/10.1038/mtna.2015.58

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