MDM2–MDM4 molecular interaction investigated by atomic force spectroscopy and surface plasmon resonance

Murine double minute 2 (MDM2) and 4 (MDM4) are known as the main negative regulators of p53, a tumor suppressor. They are able to form heterodimers that are much more effective in the downregulation of p53. Therefore, the MDM2–MDM4 complex could be a target for promising therapeutic restoration of p...

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Detalles Bibliográficos
Autores principales: Moscetti, Ilaria, Teveroni, Emanuela, Moretti, Fabiola, Bizzarri, Anna Rita, Cannistraro, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012629/
https://www.ncbi.nlm.nih.gov/pubmed/27621617
http://dx.doi.org/10.2147/IJN.S114705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012629/
https://www.ncbi.nlm.nih.gov/pubmed/27621617
http://dx.doi.org/10.2147/IJN.S114705

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