Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans

Dysregulation of splicing factor expression and altered alternative splicing are associated with aging in humans and other species, and also with replicative senescence in cultured cells. Here, we assess whether expression changes of key splicing regulator genes and consequent effects on alternative...

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Detalles Bibliográficos
Autores principales: Lee, Benjamin P., Pilling, Luke C., Emond, Florence, Flurkey, Kevin, Harrison, David E., Yuan, Rong, Peters, Luanne L., Kuchel, George A., Ferrucci, Luigi, Melzer, David, Harries, Lorna W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013025/
https://www.ncbi.nlm.nih.gov/pubmed/27363602
http://dx.doi.org/10.1111/acel.12499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013025/
https://www.ncbi.nlm.nih.gov/pubmed/27363602
http://dx.doi.org/10.1111/acel.12499

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