Aggregation tendencies in the p53 family are modulated by backbone hydrogen bonds

The p53 family of proteins is comprised of p53, p63 and p73. Because the p53 DNA binding domain (DBD) is naturally unstable and possesses an amyloidogenic sequence, it is prone to form amyloid fibrils, causing loss of functions. To develop p53 therapies, it is necessary to understand the molecular b...

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Detalles Bibliográficos
Autores principales: Cino, Elio A., Soares, Iaci N., Pedrote, Murilo M., de Oliveira, Guilherme A. P., Silva, Jerson L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013286/
https://www.ncbi.nlm.nih.gov/pubmed/27600721
http://dx.doi.org/10.1038/srep32535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013286/
https://www.ncbi.nlm.nih.gov/pubmed/27600721
http://dx.doi.org/10.1038/srep32535

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