A proposed preventive role for Gamma-hydroxybutyrate (Xyrem(R)) in Alzheimer’s disease

Gamma-hydroxybutyrate (GHB or Xyrem(R)) is frequently used in humans for several clinical indications, including anesthesia, narcolepsy/cataplexy, and alcohol-withdrawal symptoms. Pharmacological effects induced in the brain by therapeutic doses of Xyrem(R) are generally GABAergic-dependent. These e...

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Detalles Bibliográficos
Autores principales: Maitre, Michel, Klein, Christian, Mensah-Nyagan, Ayikoe G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013588/
https://www.ncbi.nlm.nih.gov/pubmed/27601032
http://dx.doi.org/10.1186/s13195-016-0205-y
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author Maitre, Michel
Klein, Christian
Mensah-Nyagan, Ayikoe G.
author_facet Maitre, Michel
Klein, Christian
Mensah-Nyagan, Ayikoe G.
author_sort Maitre, Michel
collection PubMed
description Gamma-hydroxybutyrate (GHB or Xyrem(R)) is frequently used in humans for several clinical indications, including anesthesia, narcolepsy/cataplexy, and alcohol-withdrawal symptoms. Pharmacological effects induced in the brain by therapeutic doses of Xyrem(R) are generally GABAergic-dependent. These effects allow sedation, stress/anxiety reduction, deep sleep induction, decrease of neuroinflammation, and neuroprotection. Furthermore, Xyrem(R) promotes the expression of pivotal genes reducing toxic proteinopathies, as demonstrated in laboratory animal models. Altogether, these data represent additional evidence to suggest that Xyrem(R) may be tested during repeated short periods in populations at risk for Alzheimer’s disease.
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spelling pubmed-50135882016-09-08 A proposed preventive role for Gamma-hydroxybutyrate (Xyrem(R)) in Alzheimer’s disease Maitre, Michel Klein, Christian Mensah-Nyagan, Ayikoe G. Alzheimers Res Ther Viewpoint Gamma-hydroxybutyrate (GHB or Xyrem(R)) is frequently used in humans for several clinical indications, including anesthesia, narcolepsy/cataplexy, and alcohol-withdrawal symptoms. Pharmacological effects induced in the brain by therapeutic doses of Xyrem(R) are generally GABAergic-dependent. These effects allow sedation, stress/anxiety reduction, deep sleep induction, decrease of neuroinflammation, and neuroprotection. Furthermore, Xyrem(R) promotes the expression of pivotal genes reducing toxic proteinopathies, as demonstrated in laboratory animal models. Altogether, these data represent additional evidence to suggest that Xyrem(R) may be tested during repeated short periods in populations at risk for Alzheimer’s disease. BioMed Central 2016-09-06 /pmc/articles/PMC5013588/ /pubmed/27601032 http://dx.doi.org/10.1186/s13195-016-0205-y Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Viewpoint
Maitre, Michel
Klein, Christian
Mensah-Nyagan, Ayikoe G.
A proposed preventive role for Gamma-hydroxybutyrate (Xyrem(R)) in Alzheimer’s disease
title A proposed preventive role for Gamma-hydroxybutyrate (Xyrem(R)) in Alzheimer’s disease
title_full A proposed preventive role for Gamma-hydroxybutyrate (Xyrem(R)) in Alzheimer’s disease
title_fullStr A proposed preventive role for Gamma-hydroxybutyrate (Xyrem(R)) in Alzheimer’s disease
title_full_unstemmed A proposed preventive role for Gamma-hydroxybutyrate (Xyrem(R)) in Alzheimer’s disease
title_short A proposed preventive role for Gamma-hydroxybutyrate (Xyrem(R)) in Alzheimer’s disease
title_sort proposed preventive role for gamma-hydroxybutyrate (xyrem(r)) in alzheimer’s disease
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013588/
https://www.ncbi.nlm.nih.gov/pubmed/27601032
http://dx.doi.org/10.1186/s13195-016-0205-y
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