EsxA membrane-permeabilizing activity plays a key role in mycobacterial cytosolic translocation and virulence: effects of single-residue mutations at glutamine 5

EsxA is required for virulence of Mycobacterium tuberculosis (Mtb) and plays an essential role in phagosome rupture and translocation to the cytosol of macrophages. Recent biochemical studies have demonstrated that EsxA is a membrane-permeabilizing protein. However, evidence that link EsxA membrane-...

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Detalles Bibliográficos
Autores principales: Zhang, Qi, Wang, Decheng, Jiang, Guozhong, Liu, Wei, Deng, Qing, Li, Xiujun, Qian, Wei, Ouellet, Hugues, Sun, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013644/
https://www.ncbi.nlm.nih.gov/pubmed/27600772
http://dx.doi.org/10.1038/srep32618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013644/
https://www.ncbi.nlm.nih.gov/pubmed/27600772
http://dx.doi.org/10.1038/srep32618

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