Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy

Chromosomal instability (CIN) is a hallmark of cancer that contributes to tumour heterogeneity and other malignant properties. Aberrant centromere and kinetochore function causes CIN through chromosome missegregation, leading to aneuploidy, rearrangements and micronucleus formation. Here we develop...

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Detalles Bibliográficos
Autores principales: Zhang, Weiguo, Mao, Jian-Hua, Zhu, Wei, Jain, Anshu K., Liu, Ke, Brown, James B., Karpen, Gary H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013662/
https://www.ncbi.nlm.nih.gov/pubmed/27577169
http://dx.doi.org/10.1038/ncomms12619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013662/
https://www.ncbi.nlm.nih.gov/pubmed/27577169
http://dx.doi.org/10.1038/ncomms12619

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