MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels

Insulin resistance is a key driver of type 2 diabetes (T2D) and is characterized by defective insulin receptor (INSR) signalling. Although surface INSR downregulation is a well-established contributor to insulin resistance, the underlying molecular mechanisms remain obscure. Here we show that the E3...

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Detalles Bibliográficos
Autores principales: Nagarajan, Arvindhan, Petersen, Max C., Nasiri, Ali R., Butrico, Gina, Fung, Annie, Ruan, Hai-Bin, Kursawe, Romy, Caprio, Sonia, Thibodeau, Jacques, Bourgeois-Daigneault, Marie-Claude, Sun, Lisha, Gao, Guangping, Bhanot, Sanjay, Jurczak, Michael J., Green, Michael R., Shulman, Gerald I., Wajapeyee, Narendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013666/
https://www.ncbi.nlm.nih.gov/pubmed/27577745
http://dx.doi.org/10.1038/ncomms12639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013666/
https://www.ncbi.nlm.nih.gov/pubmed/27577745
http://dx.doi.org/10.1038/ncomms12639

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