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Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice
Insulin-producing β cells become dedifferentiated during diabetes progression. An impaired ability to select substrates for oxidative phosphorylation, or metabolic inflexibility, initiates progression from β-cell dysfunction to β-cell dedifferentiation. The identification of pathways involved in ded...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013715/ https://www.ncbi.nlm.nih.gov/pubmed/27572106 http://dx.doi.org/10.1038/ncomms12631 |