A simple yet accurate correction for winner's curse can predict signals discovered in much larger genome scans

Motivation: For genetic studies, statistically significant variants explain far less trait variance than ‘sub-threshold’ association signals. To dimension follow-up studies, researchers need to accurately estimate ‘true’ effect sizes at each SNP, e.g. the true mean of odds ratios (ORs)/regression co...

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Detalles Bibliográficos
Autores principales: Bigdeli, T. Bernard, Lee, Donghyung, Webb, Bradley Todd, Riley, Brien P., Vladimirov, Vladimir I., Fanous, Ayman H., Kendler, Kenneth S., Bacanu, Silviu-Alin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013908/
https://www.ncbi.nlm.nih.gov/pubmed/27187203
http://dx.doi.org/10.1093/bioinformatics/btw303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013908/
https://www.ncbi.nlm.nih.gov/pubmed/27187203
http://dx.doi.org/10.1093/bioinformatics/btw303

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