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A simple yet accurate correction for winner's curse can predict signals discovered in much larger genome scans
Motivation: For genetic studies, statistically significant variants explain far less trait variance than ‘sub-threshold’ association signals. To dimension follow-up studies, researchers need to accurately estimate ‘true’ effect sizes at each SNP, e.g. the true mean of odds ratios (ORs)/regression co...
Autores principales: | Bigdeli, T. Bernard, Lee, Donghyung, Webb, Bradley Todd, Riley, Brien P., Vladimirov, Vladimir I., Fanous, Ayman H., Kendler, Kenneth S., Bacanu, Silviu-Alin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013908/ https://www.ncbi.nlm.nih.gov/pubmed/27187203 http://dx.doi.org/10.1093/bioinformatics/btw303 |
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