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Linear models of activation cascades: analytical solutions and coarse-graining of delayed signal transduction

Cellular signal transduction usually involves activation cascades, the sequential activation of a series of proteins following the reception of an input signal. Here, we study the classic model of weakly activated cascades and obtain analytical solutions for a variety of inputs. We show that in the...

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Detalles Bibliográficos
Autores principales: Beguerisse-Díaz, Mariano, Desikan, Radhika, Barahona, Mauricio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014067/
https://www.ncbi.nlm.nih.gov/pubmed/27581482
http://dx.doi.org/10.1098/rsif.2016.0409