Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight into Ternary Complex Formation with LRP6 and Dickkopf

Kremen 1 and 2 have been identified as co-receptors for Dickkopf (Dkk) proteins, hallmark secreted antagonists of canonical Wnt signaling. We present here three crystal structures of the ectodomain of human Kremen1 (KRM1(ECD)) at resolutions between 1.9 and 3.2 Å. KRM1(ECD) emerges as a rigid molecu...

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Detalles Bibliográficos
Autores principales: Zebisch, Matthias, Jackson, Verity A., Zhao, Yuguang, Jones, E. Yvonne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Short Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014086/
https://www.ncbi.nlm.nih.gov/pubmed/27524201
http://dx.doi.org/10.1016/j.str.2016.06.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014086/
https://www.ncbi.nlm.nih.gov/pubmed/27524201
http://dx.doi.org/10.1016/j.str.2016.06.020

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