CLD1 Reverses the Ubiquinone Insufficiency of Mutant cat5/coq7 in a Saccharomyces cerevisiae Model System

Ubiquinone (Q(n)) functions as a mobile electron carrier in mitochondria. In humans, Q biosynthetic pathway mutations lead to Q(10) deficiency, a life threatening disorder. We have used a Saccharomyces cerevisiae model of Q(6) deficiency to screen for new modulators of ubiquinone biosynthesis. We ge...

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Detalles Bibliográficos
Autores principales: Kar, Adwitiya, Beam, Haley, Borror, Megan B., Luckow, Michael, Gao, Xiaoli, Rea, Shane L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014327/
https://www.ncbi.nlm.nih.gov/pubmed/27603010
http://dx.doi.org/10.1371/journal.pone.0162165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014327/
https://www.ncbi.nlm.nih.gov/pubmed/27603010
http://dx.doi.org/10.1371/journal.pone.0162165

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