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CLD1 Reverses the Ubiquinone Insufficiency of Mutant cat5/coq7 in a Saccharomyces cerevisiae Model System
Ubiquinone (Q(n)) functions as a mobile electron carrier in mitochondria. In humans, Q biosynthetic pathway mutations lead to Q(10) deficiency, a life threatening disorder. We have used a Saccharomyces cerevisiae model of Q(6) deficiency to screen for new modulators of ubiquinone biosynthesis. We ge...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014327/ https://www.ncbi.nlm.nih.gov/pubmed/27603010 http://dx.doi.org/10.1371/journal.pone.0162165 |