A Translational Study of a New Therapeutic Approach for Acute Myocardial Infarction: Nanoparticle-Mediated Delivery of Pitavastatin into Reperfused Myocardium Reduces Ischemia-Reperfusion Injury in a Preclinical Porcine Model

BACKGROUND: There is an unmet need to develop an innovative cardioprotective modality for acute myocardial infarction, for which interventional reperfusion therapy is hampered by ischemia-reperfusion (IR) injury. We recently reported that bioabsorbable poly(lactic acid/glycolic acid) (PLGA) nanopart...

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Detalles Bibliográficos
Autores principales: Ichimura, Kenzo, Matoba, Tetsuya, Nakano, Kaku, Tokutome, Masaki, Honda, Katsuya, Koga, Jun-ichiro, Egashira, Kensuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014419/
https://www.ncbi.nlm.nih.gov/pubmed/27603665
http://dx.doi.org/10.1371/journal.pone.0162425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014419/
https://www.ncbi.nlm.nih.gov/pubmed/27603665
http://dx.doi.org/10.1371/journal.pone.0162425

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