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DNA as Tunable Adaptor for siRNA Polyplex Stabilization and Functionalization
siRNA and microRNA are promising therapeutic agents, which are engaged in a natural mechanism called RNA interference that modulates gene expression posttranscriptionally. For intracellular delivery of such nucleic acid triggers, we use sequence-defined cationic polymers manufactured through solid p...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014462/ https://www.ncbi.nlm.nih.gov/pubmed/26928236 http://dx.doi.org/10.1038/mtna.2016.6 |