Disposition and Pharmacology of a GalNAc(3)-conjugated ASO Targeting Human Lipoprotein (a) in Mice

Triantennary N-acetyl galactosamine (GalNAc(3))-conjugated antisense oligonucleotides (ASOs) have greatly improved potency via receptor-mediated uptake. In the present study, the in vivo pharmacology of a 2′-O-(2-methoxyethyl)-modified ASO conjugated with GalNAc(3) (ISIS 681257) together with its un...

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Detalles Bibliográficos
Autores principales: Yu, Rosie Z, Graham, Mark J, Post, Noah, Riney, Stan, Zanardi, Thomas, Hall, Shannon, Burkey, Jennifer, Shemesh, Colby S, Prakash, Thazha P, Seth, Punit P, Swayze, Eric E, Geary, Richard S, Wang, Yanfeng, Henry, Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014512/
https://www.ncbi.nlm.nih.gov/pubmed/27138177
http://dx.doi.org/10.1038/mtna.2016.26

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014512/
https://www.ncbi.nlm.nih.gov/pubmed/27138177
http://dx.doi.org/10.1038/mtna.2016.26

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