Targeting TSLP With shRNA Alleviates Airway Inflammation and Decreases Epithelial CCL17 in a Murine Model of Asthma

Airway epithelium defends the invasion from microorganisms and regulates immune responses in allergic asthma. Thymic stromal lymphopoietin (TSLP) from inflamed epithelium promotes maturation of dendritic cells (DCs) to prime Th2 responses via CCL17, which induces chemotaxis of CD4(+) T cells to medi...

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Detalles Bibliográficos
Autores principales: Chen, Yi-Lien, Chiang, Bor-Luen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014514/
https://www.ncbi.nlm.nih.gov/pubmed/27138176
http://dx.doi.org/10.1038/mtna.2016.29

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014514/
https://www.ncbi.nlm.nih.gov/pubmed/27138176
http://dx.doi.org/10.1038/mtna.2016.29

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