Cargando…

Development of a Safeguard System Using an Episomal Mammalian Artificial Chromosome for Gene and Cell Therapy

The development of a safeguard system to remove tumorigenic cells would allow safer clinical applications of stem cells for the treatment of patients with an intractable disease including genetic disorders. Such safeguard systems should not disrupt the host genome and should have long-term stability...

Descripción completa

Detalles Bibliográficos
Autores principales:	Uno, Narumi, Uno, Katsuhiro, Komoto, Shinya, Suzuki, Teruhiko, Hiratsuka, Masaharu, Osaki, Mitsuhiko, Kazuki, Yasuhiro, Oshimura, Mitsuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014537/ https://www.ncbi.nlm.nih.gov/pubmed/26670279 http://dx.doi.org/10.1038/mtna.2015.45

Ejemplares similares

CRISPR/Cas9-induced transgene insertion and telomere-associated truncation of a single human chromosome for chromosome engineering in CHO and A9 cells
por: Uno, Narumi, et al.
Publicado: (2017)

Retargeting of microcell fusion towards recipient cell-oriented transfer of human artificial chromosome
por: Hiratsuka, Masaharu, et al.
Publicado: (2015)

A luciferase complementation assay system using transferable mouse artificial chromosomes to monitor protein–protein interactions mediated by G protein-coupled receptors
por: Uno, Narumi, et al.
Publicado: (2018)

Integration-Free iPS Cells Engineered Using Human Artificial Chromosome Vectors
por: Hiratsuka, Masaharu, et al.
Publicado: (2011)

Panel of human cell lines with human/mouse artificial chromosomes
por: Uno, Narumi, et al.
Publicado: (2022)

A pathway from chromosome transfer to engineering resulting in human and mouse artificial chromosomes for a variety of applications to bio-medical challenges
por: Oshimura, Mitsuo, et al.
Publicado: (2015)

An efficient protein production system via gene amplification on a human artificial chromosome and the chromosome transfer to CHO cells
por: Ohira, Takahito, et al.
Publicado: (2019)

Development of a multiple-gene-loading method by combining multi-integration system-equipped mouse artificial chromosome vector and CRISPR-Cas9
por: Honma, Kazuhisa, et al.
Publicado: (2018)

Full-length human dystrophin on human artificial chromosome compensates for mouse dystrophin deficiency in a Duchenne muscular dystrophy mouse model
por: Hiramuki, Yosuke, et al.
Publicado: (2023)

Engineering of human induced pluripotent stem cells via human artificial chromosome vectors for cell therapy and disease modeling
por: Kazuki, Yasuhiro, et al.
Publicado: (2020)

A Novel System for Simultaneous or Sequential Integration of Multiple Gene-Loading Vectors into a Defined Site of a Human Artificial Chromosome
por: Suzuki, Teruhiko, et al.
Publicado: (2014)

A Human Artificial Chromosome Recapitulates the Metabolism of Native Telomeres in Mammalian Cells
por: Wakai, Michihito, et al.
Publicado: (2014)

Treatment of CHO cells with Taxol and reversine improves micronucleation and microcell-mediated chromosome transfer efficiency
por: Uno, Narumi, et al.
Publicado: (2023)

Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome
por: Ohta, Yumi, et al.
Publicado: (2020)

Transfer of a Mouse Artificial Chromosome into Spermatogonial Stem Cells Generates Transchromosomic Mice
por: Shinohara, Takashi, et al.
Publicado: (2017)

Highly Efficient Transfer of Chromosomes to a Broad Range of Target Cells Using Chinese Hamster Ovary Cells Expressing Murine Leukemia Virus-Derived Envelope Proteins
por: Suzuki, Teruhiko, et al.
Publicado: (2016)

Simultaneous loading of PCR-based multiple fragments on mouse artificial chromosome vectors in DT40 cell for gene delivery
por: Yamazaki, Kyotaro, et al.
Publicado: (2022)

Establishment of a novel hepatocyte model that expresses four cytochrome P450 genes stably via mammalian-derived artificial chromosome for pharmacokinetics and toxicity studies
por: Satoh, Daisuke, et al.
Publicado: (2017)

Construction of stable mouse artificial chromosome from native mouse chromosome 10 for generation of transchromosomic mice
por: Abe, Satoshi, et al.
Publicado: (2021)

Publisher Correction: Simultaneous loading of PCR-based multiple fragments on mouse artificial chromosome vectors in DT40 cell for gene delivery
por: Yamazaki, Kyotaro, et al.
Publicado: (2023)

Complete restoration of multiple dystrophin isoforms in genetically corrected Duchenne muscular dystrophy patient–derived cardiomyocytes
por: Zatti, Susi, et al.
Publicado: (2014)

Complete Genetic Correction of iPS Cells From Duchenne Muscular Dystrophy
por: Kazuki, Yasuhiro, et al.
Publicado: (2009)

Establishment and Characterization of a Transgenic Mouse Model for In Vivo Imaging of Bmp4 Expression in the Pancreas
por: Yasunaga, Mayu, et al.
Publicado: (2011)

A Method for Producing Transgenic Cells Using a Multi-Integrase System on a Human Artificial Chromosome Vector
por: Yamaguchi, Shigeyuki, et al.
Publicado: (2011)

Reversible immortalisation enables genetic correction of human muscle progenitors and engineering of next‐generation human artificial chromosomes for Duchenne muscular dystrophy
por: Benedetti, Sara, et al.
Publicado: (2017)

Prospects for the Use of Artificial Chromosomes and Minichromosome-Like Episomes in Gene Therapy
por: Pérez-Luz, Sara, et al.
Publicado: (2010)

Mouse embryonic stem cells with a multi-integrase mouse artificial chromosome for transchromosomic mouse generation
por: Yoshimura, Yuki, et al.
Publicado: (2015)

Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model
por: Kazuki, Yasuhiro, et al.
Publicado: (2016)

Use of a Human Artificial Chromosome for Delivering Trophic Factors in a Rodent Model of Amyotrophic Lateral Sclerosis
por: Watanabe, Yasuhiro, et al.
Publicado: (2015)

MTA1, a metastasis-associated protein, in endothelial cells is an essential molecule for angiogenesis
por: Ishikawa, Mizuho, et al.
Publicado: (2022)

Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies
por: Kazuki, Yasuhiro, et al.
Publicado: (2014)

Real‐time fluorometric evaluation of hepatoblast proliferation in vivo and in vitro using the expression of CYP3A7 coding for human fetus‐specific P450
por: Okuyama, Shota, et al.
Publicado: (2020)

A kidney injury molecule‐1 (Kim‐1) gene reporter in a mouse artificial chromosome: the responsiveness to cisplatin toxicity in immortalized mouse kidney S3 cells
por: Kokura, Kenji, et al.
Publicado: (2016)

Multiple expression cassette exchange via TP901‐1, R4, and Bxb1 integrase systems on a mouse artificial chromosome
por: Tomimatsu, Kosuke, et al.
Publicado: (2017)

Refined human artificial chromosome vectors for gene therapy and animal transgenesis
por: Kazuki, Y, et al.
Publicado: (2011)

Episomal and chromosomal DNA replication and recombination in Entamoeba histolytica
por: Bhattacharya, Sudha
Publicado: (2023)

A novel all-in-one conditional knockout system uncovered an essential role of DDX1 in ribosomal RNA processing
por: Suzuki, Teruhiko, et al.
Publicado: (2021)

Fidelity of end joining in mammalian episomes and the impact of Metnase on joint processing
por: Rath, Abhijit, et al.
Publicado: (2014)

Human Artificial Chromosome with a Conditional Centromere for Gene Delivery and Gene Expression
por: Iida, Yuichi, et al.
Publicado: (2010)

Exploitation of the interaction of measles virus fusogenic envelope proteins with the surface receptor CD46 on human cells for microcell-mediated chromosome transfer
por: Katoh, Motonobu, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_j3ou2lsd7rpps3tb189puaifcr