Patched1 and Patched2 inhibit Smoothened non-cell autonomously

Smoothened (Smo) inhibition by Patched (Ptch) is central to Hedgehog (Hh) signaling. Ptch, a proton driven antiporter, is required for Smo inhibition via an unknown mechanism. Hh ligand binding to Ptch reverses this inhibition and activated Smo initiates the Hh response. To determine whether Ptch in...

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Detalles Bibliográficos
Autores principales: Roberts, Brock, Casillas, Catalina, Alfaro, Astrid C, Jägers, Carina, Roelink, Henk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014547/
https://www.ncbi.nlm.nih.gov/pubmed/27552050
http://dx.doi.org/10.7554/eLife.17634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014547/
https://www.ncbi.nlm.nih.gov/pubmed/27552050
http://dx.doi.org/10.7554/eLife.17634

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