Cargando…
Patched1 and Patched2 inhibit Smoothened non-cell autonomously
Smoothened (Smo) inhibition by Patched (Ptch) is central to Hedgehog (Hh) signaling. Ptch, a proton driven antiporter, is required for Smo inhibition via an unknown mechanism. Hh ligand binding to Ptch reverses this inhibition and activated Smo initiates the Hh response. To determine whether Ptch in...
Autores principales: | Roberts, Brock, Casillas, Catalina, Alfaro, Astrid C, Jägers, Carina, Roelink, Henk |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014547/ https://www.ncbi.nlm.nih.gov/pubmed/27552050 http://dx.doi.org/10.7554/eLife.17634 |
Ejemplares similares
-
Core promoter factor TAF9B regulates neuronal gene expression
por: Herrera, Francisco J, et al.
Publicado: (2014) -
Requirement of Smurf-mediated endocytosis of Patched1 in sonic
hedgehog signal reception
por: Yue, Shen, et al.
Publicado: (2014) -
An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1
por: Lorberbaum, David S, et al.
Publicado: (2016) -
Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations
por: GALIMBERTI, FABRIZIO, et al.
Publicado: (2012) -
Regulation of Smoothened Trafficking and Abundance in Hedgehog Signaling
por: Jia, Jianhang, et al.
Publicado: (2022)