DAMGO modulates two-pore domain K(+) channels in the substantia gelatinosa neurons of rat spinal cord

The analgesic mechanism of opioids is known to decrease the excitability of substantia gelatinosa (SG) neurons receiving the synaptic inputs from primary nociceptive afferent fiber by increasing inwardly rectifying K(+) current. In this study, we examined whether a µ-opioid agonist, [D-Ala2,N-Me-Phe...

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Detalles Bibliográficos
Autores principales: Cho, Pyung Sun, Lee, Han Kyu, Lee, Sang Hoon, Im, Jay Zoon, Jung, Sung Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014999/
https://www.ncbi.nlm.nih.gov/pubmed/27610039
http://dx.doi.org/10.4196/kjpp.2016.20.5.525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014999/
https://www.ncbi.nlm.nih.gov/pubmed/27610039
http://dx.doi.org/10.4196/kjpp.2016.20.5.525

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