Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGFβ-1 signaling by de-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosis

Transforming growth factor β-1 (TGFβ-1)-induced phosphorylation of transcription factors Smad2 and Smad3 plays a crucial role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). However, the molecular regulation of Smad2/Smad3 proteins stability remains a mystery. Here, we show that ubiquiti...

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Detalles Bibliográficos
Autores principales: Nan, Ling, Jacko, Anastasia M., Tan, Jiangning, Wang, Dan, Zhao, Jing, Kass, Daniel J., Ma, Haichun, Zhao, Yutong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015047/
https://www.ncbi.nlm.nih.gov/pubmed/27604640
http://dx.doi.org/10.1038/srep33116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015047/
https://www.ncbi.nlm.nih.gov/pubmed/27604640
http://dx.doi.org/10.1038/srep33116

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