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Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGFβ-1 signaling by de-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosis

Transforming growth factor β-1 (TGFβ-1)-induced phosphorylation of transcription factors Smad2 and Smad3 plays a crucial role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). However, the molecular regulation of Smad2/Smad3 proteins stability remains a mystery. Here, we show that ubiquiti...

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Detalles Bibliográficos
Autores principales:	Nan, Ling, Jacko, Anastasia M., Tan, Jiangning, Wang, Dan, Zhao, Jing, Kass, Daniel J., Ma, Haichun, Zhao, Yutong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015047/ https://www.ncbi.nlm.nih.gov/pubmed/27604640 http://dx.doi.org/10.1038/srep33116

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