Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine

Cancer cells have altered metabolism compared to normal cells, including dependence on glutamine (GLN) for survival, known as GLN addiction. However, some cancer cell lines do not require GLN for survival and the basis for this discrepancy is not well understood. GLN is a precursor for antioxidants...

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Detalles Bibliográficos
Autores principales: Cetinbas, Naniye Mallı, Sudderth, Jessica, Harris, Robert C., Cebeci, Aysun, Negri, Gian L., Yılmaz, Ömer H., DeBerardinis, Ralph J., Sorensen, Poul H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015067/
https://www.ncbi.nlm.nih.gov/pubmed/27605385
http://dx.doi.org/10.1038/srep32606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015067/
https://www.ncbi.nlm.nih.gov/pubmed/27605385
http://dx.doi.org/10.1038/srep32606

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