Enhancing Endosomal Escape for Intracellular Delivery of Macromolecular Biologic Therapeutics

Bioactive macromolecular peptides and oligonucleotides have significant therapeutic potential. However, due to their size, they have no ability to enter the cytoplasm of cells. Peptide/Protein transduction domains (PTDs), also called cell-penetrating peptides (CPPs), can promote uptake of macromolec...

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Detalles Bibliográficos
Autores principales: Lönn, Peter, Kacsinta, Apollo D., Cui, Xian-Shu, Hamil, Alexander S., Kaulich, Manuel, Gogoi, Khirud, Dowdy, Steven F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015074/
https://www.ncbi.nlm.nih.gov/pubmed/27604151
http://dx.doi.org/10.1038/srep32301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015074/
https://www.ncbi.nlm.nih.gov/pubmed/27604151
http://dx.doi.org/10.1038/srep32301

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