Nedd4-2 haploinsufficiency causes hyperactivity and increased sensitivity to inflammatory stimuli

Nedd4-2 (NEDD4L in humans) is a ubiquitin protein ligase best known for its role in regulating ion channel internalization and turnover. Nedd4-2 deletion in mice causes perinatal lethality associated with increased epithelial sodium channel (ENaC) expression in lung and kidney. Abundant data suggest...

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Detalles Bibliográficos
Autores principales: Yanpallewar, Sudhirkumar, Wang, Ting, Koh, Dawn C. I., Quarta, Eros, Fulgenzi, Gianluca, Tessarollo, Lino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015076/
https://www.ncbi.nlm.nih.gov/pubmed/27604420
http://dx.doi.org/10.1038/srep32957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015076/
https://www.ncbi.nlm.nih.gov/pubmed/27604420
http://dx.doi.org/10.1038/srep32957

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