Selected polyphenols potentiate the apoptotic efficacy of glycolytic inhibitors in human acute myeloid leukemia cell lines. Regulation by protein kinase activities

BACKGROUND: The glycolysis inhibitor 2-deoxy-d-glucose (2-DG) is a safe, potentially useful anti-tumour drug, but its efficacy is normally low when used alone. Recent studies indicated that 2-DG stimulates the PI3K/Akt and MEK/ERK defensive pathways, which limits the apoptotic efficacy in tumour cel...

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Detalles Bibliográficos
Autores principales: de Blas, Elena, Estañ, María Cristina, del Carmen Gómez de Frutos, María, Ramos, Javier, del Carmen Boyano-Adánez, María, Aller, Patricio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015235/
https://www.ncbi.nlm.nih.gov/pubmed/27610044
http://dx.doi.org/10.1186/s12935-016-0345-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015235/
https://www.ncbi.nlm.nih.gov/pubmed/27610044
http://dx.doi.org/10.1186/s12935-016-0345-y

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