A Split-Ubiquitin Based Strategy Selecting for Protein Complex-Interfering Mutations

Understanding the topologies and functions of protein interaction networks requires the selective removal of single interactions. We introduce a selection strategy that enriches among a random library of alleles for mutations that impair the binding to a given partner protein. The selection makes us...

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Detalles Bibliográficos
Autores principales: Gronemeyer, Thomas, Chollet, Julian, Werner, Stefan, Glomb, Oliver, Bäuerle, Anne, Johnsson, Nils
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2016
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015938/
https://www.ncbi.nlm.nih.gov/pubmed/27402358
http://dx.doi.org/10.1534/g3.116.031369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015938/
https://www.ncbi.nlm.nih.gov/pubmed/27402358
http://dx.doi.org/10.1534/g3.116.031369

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